In terms of kidney health, cyclosporine is a more effective long-term maintenance therapy for people with lupus nephritis than either mycophenolate mofetil or azathioprine, new data suggest.
Largely, the researchers drew this conclusion because patients using it — even in the presence of high urine protein levels — went into remission more quickly than those on the other treatments, and stayed stable comparatively well.
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The Findings
These findings were detailed at the Annual European Congress of Rheumatology (EULAR 2019) in a presentation titled, “Multicenter Study Comparing Cyclosporine, Mycophenolate Mofetil and Azathioprine in the Maintenance Therapy of Lupus Nephritis: 10 Year Follow Up.”
Lupus nephritis – inflammation of the kidneys caused by systemic lupus erythematosus (SLE) – is “a serious condition requiring early aggressive therapy to achieve remission,” John D. Isaacs, PhD, chairperson of the Abstract Selection Committee at EULAR, said in a press release. “However, the type and duration of immunosuppression after achieving response remain a matter of controversy.”